Article
Transformation and pH homeostasis of fibroblasts expressing yeast H(+)-ATPase containing site-directed mutations.
Molecular and cellular biology - 1 Aug 1990
Perona R, Portillo F, Giraldez F, Serrano R
Abstract excerpt
Mouse fibroblasts expressing a yeast proton-pumping ATPase show tumorigenic transformation (R. Perona, and R. Serrano, Nature (London) 334:438-440, 1988). By expressing site-directed mutations of the yeast ATPase with different levels of activity, a close correlation has been found between enzyme...
Topics
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Cells, Cultured
- DNA Replication
- Fibroblasts
- Homeostasis
- Hydrogen-Ion Concentration
- Kinetics
- Membrane Potentials
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Proton-Translocating ATPases
- Saccharomyces cerevisiae
- Thymidine
- Transfection