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Article

Transformation and pH homeostasis of fibroblasts expressing yeast H(+)-ATPase containing site-directed mutations.

Molecular and cellular biology - 1 Aug 1990

Perona R, Portillo F, Giraldez F, Serrano R

Abstract excerpt

Mouse fibroblasts expressing a yeast proton-pumping ATPase show tumorigenic transformation (R. Perona, and R. Serrano, Nature (London) 334:438-440, 1988). By expressing site-directed mutations of the yeast ATPase with different levels of activity, a close correlation has been found between enzyme activity, tumorigenic transformation, and intracellular pH measured by weak-acid distribution. Fibroblasts expressing...

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Identifiers

PMID: 2142513
DOI: 10.1128/mcb.10.8.4110-4115.1990
PMCID: PMC360931

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