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Article

New phenotypes of functional expression of the mKir2.1 channel in potassium efflux-deficient Saccharomyces cerevisiae strains.

Yeast (Chichester, England) - 1 Dec 2005

Kolacna Lucie, Zimmermannova Olga, Hasenbrink Guido, Schwarzer Sarah, Ludwig Jost, Lichtenberg-Fraté Hella, Sychrova Hana

Abstract excerpt

The functional expression of the mouse Kir2.1 potassium channel in yeast cells lacking transport systems for potassium and sodium efflux (ena1-4delta nha1delta) resulted in increased cell sensitivity to high external concentrations of potassium. The phenotype depended on the level of Kir2.1 expression and on the external pH. The activity of Kir2.1p in the yeast cells was almost negligible at pH 3.0 and the...

Topics

Barium
Ion Transport
Metals, Alkali
Phenotype
Potassium
Potassium Channels, Inwardly Rectifying
Saccharomyces cerevisiae
Transformation, Genetic

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 16358319
DOI: 10.1002/yea.1333

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