Article
Analysis of T cell receptor V beta gene usage in primary mixed lymphocyte reactions: evidence for directive usage by different antigen-presenting cells and Mls-like determinants on T cell blasts.
European journal of immunology - 1 Jun 1990
Larsson-Sciard E L, Spetz-Hagberg A L, Casrouge A, Kourilsky P
Abstract excerpt
The usage of four different T cell receptor (TcR) V beta gene families within normal, non-primed T cell populations in response to various types of antigen-presenting cells (APC) in primary mixed lymphocyte reaction has been studied. We demonstrate that distinct patterns of V beta gene usage are obtained within a given T cell population in response to different types of APC with the same allo-H-2. When responder...
Topics
- Animals
- Antigen-Presenting Cells
- Antigens, Surface
- B-Lymphocytes
- Female
- Gene Expression Regulation
- Genotype
- Histocompatibility Antigens Class I
- In Vitro Techniques
- Lymphocyte Culture Test, Mixed