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Article

Sensing NAD metabolites through macro domains

1 Jan 2009

Abstract excerpt

The macro module is a globular protein domain of about 25 kDa that is evolutionarily conserved in organisms from viruses, bacteria, yeast to humans. It is generally part of proteins that have wide-ranging (and yet to be discovered) cellular functions. There are several examples of macro domains associated with modules showing homology to poly-ADP-ribosyl-polymerases. Many macro domains, including those of the...

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PMID: 19273270
DOI: 10.2741/3448

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