Article
Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes.
Diabetes research and clinical practice - 1 Jun 2011
Katakami N, Kaneto H, Takahara M, Matsuoka T A, Imamura K, Ishibashi F, Kanda T, Kawai K, Osonoi T, Matsuhisa M, Kashiwagi A, Kawamori R, Shimomura I, Yamasaki Y
Abstract excerpt
It is likely that the C allele of the polymorphism at position -106 in the promoter of aldose reductase gene, which codes a rate-limiting enzyme of the polyol pathway, is a susceptibility allele for diabetic retinopathy in Japanese type 2 diabetic patients.
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