Article
Polymorphisms and functions of the aldose reductase gene 5' regulatory region in Chinese patients with type 2 diabetes mellitus.
Chinese medical journal - 1 Feb 2002
Li Qingjie, Xie Ping, Huang Jianjun, Gu Yapeng, Zeng Weimin, Song Huiping
Abstract excerpt
OBJECTIVE: To screen the 5' regulatory region of the aldose reductase (AR) gene for genetic variabilities causing changes in protein expression and affecting the promoter function. METHODS: The screenings were carried out by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP). All SSCP variants were submitted for DNA sequencing and inserted into the plasmid chloromycetin acetyl...
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