Article
The -106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes.
Molecular genetics and metabolism - 1 Jul 2006
dos Santos Kátia Gonçalves, Canani Luís Henrique, Gross Jorge Luiz, Tschiedel Balduíno, Souto Kátia Elisabete Pires, Roisenberg Israel
Abstract excerpt
Diabetic retinopathy is a sight-threatening chronic complication of diabetes mellitus and is the leading cause of acquired blindness in adults. The -106C>T polymorphism in the promoter region of the aldose reductase (AR) gene has been shown to be associated with the susceptibility to diabetic nephropathy in type 2 diabetes, but the findings regarding the occurrence of diabetic retinopathy are conflicting. In this...
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