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Article

Polymorphisms of the aldose reductase gene and susceptibility to retinopathy in type 1 diabetes mellitus.

Investigative ophthalmology & visual science - 1 Dec 2000

Demaine A, Cross D, Millward A

Abstract excerpt

PURPOSE: Aldose reductase (ALR2) is the first and rate-limiting enzyme of the polyol pathway and is involved in the pathogenesis of diabetic retinopathy. Polymorphisms of the ALR2 gene are associated with susceptibility to diabetic retinopathy in Chinese and Japanese patients with type 2 diabetes. There are no reports investigating these polymorphisms in white patients with type 1 diabetes from either Western...

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PMID: 11095596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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