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Article

C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy.

Diabetes research and clinical practice - 1 Nov 2006

Olmos Pablo, Bastías María-Juliana, Vollrath Valeska, Toro Luis, Trincado Arturo, Salinas Pablo, Claro Juan-Carlos, López José-Manuel, Acosta Ana-María, Miquel Juan-Francisco, Castro Juan

Abstract excerpt

PURPOSE: To study the C(-106)T polymorphism in the promoter of the aldose reductase (ALR2) gene: (a) its local prevalence and (b) its modulation of the susceptibility for developing retinopathy. METHODS: DNAs of 96 control subjects and 53 long-standing (duration 17.9+/-5.4 years) type-2 diabetic patients were analyzed by PCR-RFLP with BfaI enzyme. Retinopathy was graded with 2-eye, 7-field fundus color...

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Reference Values
Aldehyde Reductase
Diabetic Retinopathy
Disease Progression
DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycated Hemoglobin

Longitudinal Studies

Polymorphism, Single Nucleotide

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PMID: 16701918
DOI: 10.1016/j.diabres.2006.03.019

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