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Article

Probing the determinants of diacylglycerol binding affinity in the C1B domain of protein kinase Cα.

Journal of molecular biology - 20 May 2011

Stewart Mikaela D, Morgan Brittany, Massi Francesca, Igumenova Tatyana I

Abstract excerpt

C1 domains are independently folded modules that are responsible for targeting their parent proteins to lipid membranes containing diacylglycerol (DAG), a ubiquitous second messenger. The DAG binding affinities of C1 domains determine the threshold concentration of DAG required for the propagatio...

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Identifiers

PMID: 21419781
DOI: 10.1016/j.jmb.2011.03.020
PMCID: PMC3489171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21419781-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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