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Article

Structure of membrane diacylglycerol kinase in lipid bilayers.

Communications biology - 5 Mar 2021

Li Jianping, Shen Yang, Chen Yanke, Zhang Zhengfeng, Ma Shaojie, Wan Qianfen, Tong Qiong, Glaubitz Clemens, Liu Maili, Yang Jun

Abstract excerpt

Diacylglycerol kinase (DgkA) is a small integral membrane protein, responsible for the ATP-dependent phosphorylation of diacylglycerol to phosphatidic acid. Its structures reported in previous studies, determined in detergent micelles by solution NMR and in monoolein cubic phase by X-ray crystallography, differ significantly. These differences point to the need to validate these detergent-based structures in...

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Identifiers

PMID: 33674677
DOI: 10.1038/s42003-021-01802-1
PMCID: PMC7935881

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