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TMB Signature-Related RCAN2 Promotes Apoptosis by Upregulating EHF/DR5 Pathway in Hepatocellular Carcinoma.

Frontiers in bioscience (Landmark edition) - 2 Jul 2024

Xu Yu-Jie, Lai Zhi-Cheng, Kan Anna, Liu Hui, Huang Yu, Lai Yue-Yuan, Weng Jie-Feng, Wu Zhao-Feng, Shi Ming, Gu Wei-Li, Zhang Shuai, He Min-Ke

Abstract excerpt

BACKGROUND: The tumour mutation burden (TMB) is a valuable indicator of the accumulation of somatic mutations, and is thought to be associated with the biological behaviour and prognosis of tumours. However, the related genetic mechanism for these association is still unclear. The aim of the present study was to identify the key gene(s) associated with TMB in hepatocellular carcinoma (HCC) and to investigate its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39082336
DOI: 10.31083/j.fbl2907243

Genes

RCAN2
EHF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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