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Article

Role of Janus kinase 3 in mucosal differentiation and predisposition to colitis.

The Journal of biological chemistry - 1 Nov 2013

Mishra Jayshree, Verma Raj K, Alpini Gianfranco, Meng Fanyin, Kumar Narendra

Abstract excerpt

Janus kinase 3 (Jak3) is a nonreceptor tyrosine kinase expressed in both hematopoietic and nonhematopoietic cells. Previously, we characterized the functions of Jak3 in cytoskeletal remodeling, epithelial wound healing, and mucosal homeostasis. However, the role of Jak3 in mucosal differentiation and inflammatory bowel disease was not known. In this report, we characterize the role of Jak3 in mucosal...

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Identifiers

PMID: 24045942
DOI: 10.1074/jbc.M113.504126
PMCID: PMC3814773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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