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Article

NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2014

Kobayashi Taku, Steinbach Erin C, Russo Steven M, Matsuoka Katsuyoshi, Nochi Tomonori, Maharshak Nitsan, Borst Luke B, Hostager Bruce, Garcia-Martinez J Victor, Rothman Paul B, Kashiwada Masaki, Sheikh Shehzad Z, Murray Peter J, Plevy Scott E

Abstract excerpt

NFIL3 is a transcription factor that regulates multiple immunologic functions. In myeloid cells, NFIL3 is IL-10 inducible and has a key role as a repressor of IL-12p40 transcription. NFIL3 is a susceptibility gene for the human inflammatory bowel diseases. In this article, we describe spontaneous colitis in Nfil3(-/-) mice. Mice lacking both Nfil3 and Il10 had severe early-onset colitis, suggesting that NFIL3 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24442434
DOI: 10.4049/jimmunol.1301819
PMCID: PMC3948213

Genes

NFIL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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