Article
An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells.
International journal of cancer - 15 Feb 2012
Houben Roland, Adam Christian, Baeurle Anne, Hesbacher Sonja, Grimm Johannes, Angermeyer Sabrina, Henzel Katharina, Hauser Stefanie, Elling Roland, Bröcker Eva-B, Gaubatz Stefan, Becker Jürgen C, Schrama David
Abstract excerpt
Merkel cell carcinoma (MCC) is a highly aggressive skin cancer that frequently harbours Merkel cell polyomavirus (MCV) DNA integrated in the genome of the tumor cells. In our study, we elaborate our recent finding that MCV-positive MCC cell lines require the expression of the viral T antigens (TA). Indeed, in a xeno-transplantation model, we prove that TA expression is essential also in an in vivo situation, as...
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