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Enhanced neuronal Met signalling levels in ALS mice delay disease onset

17 Mar 2011

Abstract excerpt

Signalling by receptor tyrosine kinases (RTKs) coordinates basic cellular processes during development and in adulthood. Whereas aberrant RTK signalling can lead to cancer, reactivation of RTKs is often found following stress or cell damage. This has led to the common belief that RTKs can counteract degenerative processes and so strategies to exploit them for therapy have been extensively explored. An...

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PMID: 21412276
DOI: 10.1038/cddis.2011.11

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