Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy.

Neurobiology of disease - 1 Jun 2024

Rhymes Elena R, Simkin Rebecca L, Qu Ji, Villarroel-Campos David, Surana Sunaina, Tong Yao, Shapiro Ryan, Burgess Robert W, Yang Xiang-Lei, Schiavo Giampietro, Sleigh James N

Abstract excerpt

Charcot-Marie-Tooth disease (CMT) is a genetic peripheral neuropathy caused by mutations in many functionally diverse genes. The aminoacyl-tRNA synthetase (ARS) enzymes, which transfer amino acids to partner tRNAs for protein synthesis, represent the largest protein family genetically linked to CMT aetiology, suggesting pathomechanistic commonalities. Dominant intermediate CMT type C (DI-CMTC) is caused by YARS1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axonal Transport
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Charcot-Marie-Tooth Disease

Share to Disease Models, Animal

Share to Mice, Transgenic

Share to Muscle, Skeletal

Share to Receptor, trkB

Share to Tyrosine-tRNA Ligase

Source

Identifiers

PMID: 38583640
DOI: 10.1016/j.nbd.2024.106501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy.PMID 38583640Read ↗

Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathySemantic proximity Read ↗

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.Semantic proximity Read ↗

Recent advances in the genetic neuropathies.Semantic proximity Read ↗

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.Semantic proximity Read ↗

Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy.Semantic proximity Read ↗

Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.Semantic proximity Read ↗

CMT-associated mutations in glycyl- and tyrosyl-tRNA synthetases exhibit similar pattern of toxicity and share common genetic modifiers in Drosophila.Semantic proximity Read ↗

Altered sensory neuron development in CMT2D mice is site-specific and linked to increased GlyRS levelsSemantic proximity Read ↗

The neuropathy-causing <i>GARS1</i> <sup> Δ <i>ETAQ</i> </sup> mutation drives pathology in subsets of motor and sensory neurons in miceSemantic proximity Read ↗

Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling.Semantic proximity Read ↗

CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.Semantic proximity Read ↗

An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.