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Article

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.

Proceedings of the National Academy of Sciences of the United States of America - 27 May 2008

Yamanaka Koji, Boillee Severine, Roberts Elizabeth A, Garcia Michael L, McAlonis-Downes Melissa, Mikse Oliver R, Cleveland Don W, Goldstein Lawrence S B

Abstract excerpt

Dominant mutations in ubiquitously expressed superoxide dismutase (SOD1) cause familial ALS by provoking premature death of adult motor neurons. To test whether mutant damage to cell types beyond motor neurons is required for the onset of motor neuron disease, we generated chimeric mice in which...

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Identifiers

PMID: 18492803
DOI: 10.1073/pnas.0802556105
PMCID: PMC2396671

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18492803-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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