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Article

The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice

27 Mar 2020

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32220666
DOI: 10.1016/j.neuron.2020.03.005

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The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 MicePMID 32220666Read ↗

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Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in miceSemantic proximity Read ↗

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PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's diseaseSemantic proximity Read ↗

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A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.Semantic proximity Read ↗

An updated evolutionary and structural study of TBK1 reveals highly conserved motifs as potential pharmacological targets in neurodegenerative diseasesSemantic proximity Read ↗

CK1δ/e-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosisSemantic proximity Read ↗

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