Article
A polymorphism in the norepinephrine transporter gene is associated with affective and cardiovascular disease through a microRNA mechanism.
Molecular psychiatry - 1 Jan 2017
Marques F Z, Eikelis N, Bayles R G, Lambert E A, Straznicky N E, Hering D, Esler M D, Head G A, Barton D A, Schlaich M P, Lambert G W
Abstract excerpt
Norepinephrine released from sympathetic nerves is removed from the neuroeffector junction via the action of the norepinephrine transporter (NET). NET impairment is evident in several clinically important conditions including major depressive disorder (MDD), panic disorder (PD), essential hypertension and the postural orthostatic tachycardia syndrome (POTS). We aimed to determine whether a single nucleotide...
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