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Article

The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets.

PLoS pathogens - 16 Sept 2010

Imai Hirotaka, Shinya Kyoko, Takano Ryo, Kiso Maki, Muramoto Yukiko, Sakabe Saori, Murakami Shin, Ito Mutsumi, Yamada Shinya, Le Mai Thi Quynh, Nidom Chairul A, Sakai-Tagawa Yuko, Takahashi Kei, Omori Yasuyuki, Noda Takeshi, Shimojima Masayuki, Kakugawa Satoshi, Goto Hideo, Iwatsuki-Horimoto Kiyoko, Horimoto Taisuke, Kawaoka Yoshihiro

Abstract excerpt

Highly pathogenic H5N1 influenza A viruses have spread across Asia, Europe, and Africa. More than 500 cases of H5N1 virus infection in humans, with a high lethality rate, have been reported. To understand the molecular basis for the high virulence of H5N1 viruses in mammals, we tested the virulence in ferrets of several H5N1 viruses isolated from humans and found A/Vietnam/UT3062/04 (UT3062) to be the most...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20862325
DOI: 10.1371/journal.ppat.1001106
PMCID: PMC2940759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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