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Article

Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1.

Journal of virology - 1 Mar 2018

Chauché C, Nogales A, Zhu H, Goldfarb D, Ahmad Shanizza A I, Gu Q, Parrish C R, Martínez-Sobrido L, Marshall J F, Murcia P R

Abstract excerpt

Influenza A viruses (IAVs) are common pathogens of birds that occasionally establish endemic infections in mammals. The processes and mechanisms that result in IAV mammalian adaptation are poorly understood. The viral nonstructural 1 (NS1) protein counteracts the interferon (IFN) response, a central component of the host species barrier. We characterized the NS1 proteins of equine influenza virus (EIV), a...

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Identifiers

PMID: 29237841
DOI: 10.1128/JVI.01875-17
PMCID: PMC5809720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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