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Article

Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets

29 Dec 2008

Abstract excerpt

The 1918 influenza pandemic was the most devastating outbreak of infectious disease in human history, accounting for about 50 million deaths worldwide. In addition to a significant number of cases of secondary bacterial pneumonia, this highly pathogenic strain of influenza A virus caused fatal primary viral pneumonia. To identify the viral gene(s) chiefly responsible for the high virulence of the 1918 virus, we...

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PMID: 19114663
DOI: 10.1073/pnas.0806959106

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