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Article

Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2011

Mizumoto Yasunari, Kyo Satoru, Kiyono Tohru, Takakura Masahiro, Nakamura Mitsuhiro, Maida Yoshiko, Mori Noriko, Bono Yukiko, Sakurai Hiroaki, Inoue Masaki

Abstract excerpt

PURPOSE: Although the KRAS mutation is one of critical genetic alterations in endometrial carcinogenesis, the downstream targets are not known. EXPERIMENTAL DESIGN: In this study, we investigated the molecular targets of KRAS signals, using tumorigenic cells with oncogenic KRAS mutation established from telomerase reverse transcriptase (TERT)-immortalized endometrial epithelial cells. RESULTS: We first confirmed...

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Source

Identifiers

PMID: 21411444
DOI: 10.1158/1078-0432.CCR-10-2291

Genes

KRAS
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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