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Article

SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study

17 Mar 2011

Abstract excerpt

SOX2 is an embryonic neural crest stem-cell transcription factor recently shown to be expressed in human melanoma and to correlate with experimental tumor growth. SOX2 binds to an enhancer region of the gene that encodes for nestin, also a neural progenitor cell biomarker. To define further the potential relationship between SOX2 and nestin, we examined co-expression patterns in 135 melanomas and 37 melanocytic...

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PMID: 21410764
DOI: 10.1111/j.1600-0625.2011.01247.x

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