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Article

Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells

8 Sept 2010

Abstract excerpt

Numerous studies support a role for Sox2 to keep stem cells and progenitor cells in an immature and proliferative state. Coexpression of Sox2 and GFAP has been found in regions of the adult brain where neural stem cells are present and in human glioma cells. In our study, we have investigated the roles of Sox2 and its counteracting partner Sox21 in human glioma cells. We show for the first time that Sox21 is...

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PMID: 20824710
DOI: 10.1002/ijc.25647

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