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Article

MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells.

PloS one - 8 Mar 2011

Li Shuqiang, Moffett Howell F, Lu Jun, Werner Lillian, Zhang Hao, Ritz Jerome, Neuberg Donna, Wucherpfennig Kai W, Brown Jennifer R, Novina Carl D

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is thought to be a disease of resting lymphocytes. However, recent data suggest that CLL cells may more closely resemble activated B cells. Using microRNA (miRNA) expression profiling of highly-enriched CLL cells from 38 patients and 9 untransformed B cells from normal donors before acute CpG activation and 5 matched B cells after acute CpG activation, we demonstrate an...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 21408091
DOI: 10.1371/journal.pone.0016956
PMCID: PMC3050979

Genes

ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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