Article
Using the emerging Collaborative Cross to probe the immune system.
Genes and immunity - 1 Jan 2014
Phillippi J, Xie Y, Miller D R, Bell T A, Zhang Z, Lenarcic A B, Aylor D L, Krovi S H, Threadgill D W, de Villena F Pardo-Manuel, Wang W, Valdar W, Frelinger J A
Abstract excerpt
The Collaborative Cross (CC) is an emerging panel of recombinant inbred (RI) mouse strains. Each strain is genetically distinct but all descended from the same eight inbred founders. In 66 strains from incipient lines of the CC (pre-CC), as well as the 8 CC founders and some of their F1 offspring, we examined subsets of lymphocytes and antigen-presenting cells. We found significant variation among the founders,...
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