Article
Pharmacogenomics in Pediatric Patients: Towards Personalized Medicine.
Paediatric drugs - 1 Aug 2016
Maagdenberg Hedy, Vijverberg Susanne J H, Bierings Marc B, Carleton Bruce C, Arets Hubertus G M, de Boer Anthonius, Maitland-van der Zee Anke H
Abstract excerpt
It is well known that drug responses differ among patients with regard to dose requirements, efficacy, and adverse drug reactions (ADRs). The differences in drug responses are partially explained by genetic variation. This paper highlights some examples of areas in which the different responses (dose, efficacy, and ADRs) are studied in children, including cancer (cisplatin), thrombosis (vitamin K antagonists),...
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