Article
A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis.
Clinical & developmental immunology - 1 Jan 2011
Oki Mie, Watanabe Norihiko, Owada Takayoshi, Oya Yoshihiro, Ikeda Kei, Saito Yasushi, Matsumura Ryutaro, Seto Yohei, Iwamoto Itsuo, Nakajima Hiroshi
Abstract excerpt
Inhibitory coreceptors are thought to play important roles in maintaining immunological homeostasis, and a defect in the negative signals from inhibitory coreceptors may lead to the development of autoimmune diseases. We have recently identified B and T lymphocyte attenuator (BTLA), a new inhibitory coreceptor expressed on immune cells, and we suggest that BTLA may be involved in the development of autoimmune...
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