Article
Association of FOXJ1 polymorphisms with systemic lupus erythematosus and rheumatoid arthritis in Korean population.
Experimental & molecular medicine - 31 Dec 2007
Li Chun-Shi, Zhang Qinggao, Lim Mi-Kyoung, Sheen Dong-Hyuk, Shim Seung-Cheol, Kim Ji-Young, Lee Shin-Seok, Yun Ki-Jung, Moon Hyung-Bae, Chung Hun-Taeg, Chae Soo-Cheon
Abstract excerpt
The forkhead-box J1 (FOXJ1) transcription factor could suppress a spontaneous activation of T cells and B cells through an induction of IkappaBbeta that results in repression of NF-kappaB activity. In Foxj1 deficiency mice, systemic autoimmune inflammation is quite common symptom. Therefore, deregulated Foxj1 is supposed to be associated with autoimmune diseases and/or other inflammatory diseases. Previously, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
