Article
Molecular requirements for T cell recognition by a major histocompatibility complex class II-restricted T cell receptor: the involvement of the fourth hypervariable loop of the Valpha domain.
The Journal of experimental medicine - 1 Feb 1999
Thatte J, Qadri A, Radu C, Ward E S
Abstract excerpt
The role of two central residues (K68, E69) of the fourth hypervariable loop of the Valpha domain (HV4alpha) in antigen recognition by an MHC class II-restricted T cell receptor (TCR) has been analyzed. The TCR recognizes the NH2-terminal peptide of myelin basic protein (Ac1-11, acetylated at NH2...
Topics
- Antigen Presentation
- CD4 Antigens
- Histocompatibility Antigens Class II
- Interleukin-2
- Lymphocyte Activation
- Models, Molecular
- Mutation
- Myelin Basic Protein
- Peptide Fragments
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes
- Transfection