Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The podocyte protein nephrin is required for cardiac vessel formation.

Human molecular genetics - 1 Jun 2011

Wagner Nicole, Morrison Harris, Pagnotta Sophie, Michiels Jean-Francois, Schwab Yannick, Tryggvason Karl, Schedl Andreas, Wagner Kay-Dietrich

Abstract excerpt

Nephrin (NPHS1) has been described as an important structural protein of kidney podocytes. Mutations in this gene lead to the Finnish-type congenital nephrotic syndrome. More recently, a role of nephrin as a signalling molecule in kidney podocytes has been identified. Here, we show that nephrin not only has a function in kidney podocytes, but is also required for cardiovascular development. Nephrin is expressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connexin 43
Share to Coronary Vessels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to Organogenesis

Share to Pericardium

Share to Podocytes

Share to Receptors, Nerve Growth Factor

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 21402589
DOI: 10.1093/hmg/ddr106

Genes

NPHS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The podocyte protein nephrin is required for cardiac vessel formation.PMID 21402589Read ↗

An update: the role of Nephrin inside and outside the kidneySemantic proximity Read ↗

Role of nephrin in cell junction formation in human nephrogenesis.Semantic proximity Read ↗

Myo1c is an unconventional myosin required for zebrafish glomerular development.Semantic proximity Read ↗

Nephrin expression in adult rodent central nervous system and its interaction with glutamate receptorsSemantic proximity Read ↗

Neuropilin1 regulates glomerular function and basement membrane composition through pericytes in the mouse kidney.Semantic proximity Read ↗

Netrin 1 directs vascular patterning and maturity in the developing kidney.Semantic proximity Read ↗

Nephrin is specifically located at the slit diaphragm of glomerular podocytes.Semantic proximity Read ↗

Nephrin-signature molecule of the glomerular podocyte?Semantic proximity Read ↗

Nephrin is involved in podocyte maturation but not survival during glomerular developmentSemantic proximity Read ↗

Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.Semantic proximity Read ↗

Primary Structure of Mouse and Rat Nephrin cDNA and Structure and Expression of the Mouse GeneSemantic proximity Read ↗

Inducible nephrin transgene expression in podocytes rescues nephrin-deficient mice from perinatal death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.