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Article

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

Annals of neurology - 1 Mar 2008

Tomiyama Takami, Nagata Tetsu, Shimada Hiroyuki, Teraoka Rie, Fukushima Akiko, Kanemitsu Hyoue, Takuma Hiroshi, Kuwano Ryozo, Imagawa Masaki, Ataka Suzuka, Wada Yasuhiro, Yoshioka Eito, Nishizaki Tomoyuki, Watanabe Yasuyoshi, Mori Hiroshi

Abstract excerpt

OBJECTIVE: Soluble oligomers of amyloid beta (Abeta), rather than amyloid fibrils, have been proposed to initiate synaptic and cognitive dysfunction in Alzheimer's disease (AD). However, there is no direct evidence in humans that this mechanism can cause AD. Here, we report a novel amyloid precursor protein (APP) mutation that may provide evidence to address this question. METHODS: A Japanese pedigree showing...

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Identifiers

PMID: 18300294
DOI: 10.1002/ana.21321

Genes

APP
PSEN1
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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