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Article

Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices.

Neuroreport - 16 Apr 2008

Takuma Hiroshi, Teraoka Rie, Mori Hiroshi, Tomiyama Takami

Abstract excerpt

We recently identified a novel amyloid precursor protein mutation (E693Delta) in familial Alzheimer's-type dementia. This mutation produces amyloid-beta (Abeta) variant lacking glutamate-22 (E22Delta), which showed enhanced oligomerization but no fibrillization. Here, we examined in-vitro toxicity of Abeta E22Delta peptide. Wild-type Abeta1-42 showed a dose-dependent (1 nM to 1 microM) cytotoxicity to cultured...

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Identifiers

PMID: 18382273
DOI: 10.1097/WNR.0b013e3282fb78c4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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