Article
Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
Clinical immunology (Orlando, Fla.) - 1 Oct 2011
Otsubo Keisuke, Kanegane Hirokazu, Kamachi Yoshiro, Kobayashi Ichiro, Tsuge Ikuya, Imaizumi Masue, Sasahara Yoji, Hayakawa Akira, Nozu Kandai, Iijima Kazumoto, Ito Shuichi, Horikawa Reiko, Nagai Yoshinori, Takatsu Kiyoshi, Mori Hisashi, Ochs Hans D, Miyawaki Toshio
Abstract excerpt
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is an autoimmune disorder caused by mutations in the FOXP3 gene, which plays a key role in the generation of CD4(+)CD25(+)regulatory T (Treg) cells. We selected CD127 as the surface marker of Treg cells to illustrate the development and function of Treg cells in IPEX syndrome. CD4(+)CD25(+)FOXP3(+) T cells, the putative Treg cells,...
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