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Article

Identification of altered function alleles that affect Bacillus subtilis PerR metal ion selectivity.

Nucleic acids research - 1 Jul 2011

Ma Zhen, Lee Jin-Won, Helmann John D

Abstract excerpt

Bacillus subtilis PerR is a Fur family repressor that senses hydrogen peroxide by metal-catalyzed oxidation. PerR contains a structural Zn(II) ion (Site 1) and a regulatory metal binding site (Site 2) that, upon association with either Mn(II) or Fe(II), allosterically activates DNA binding. In addition, a third less conserved metal binding site (Site 3) is present near the dimer interface in several crystal...

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Identifiers

PMID: 21398634
DOI: 10.1093/nar/gkr095
PMCID: PMC3130269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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