Article
Sequential binding and sensing of Zn(II) by Bacillus subtilis Zur.
Nucleic acids research - 1 Nov 2011
Ma Zhen, Gabriel Scott E, Helmann John D
Abstract excerpt
Bacillus subtilis Zur (BsZur) represses high-affinity zinc-uptake systems and alternative ribosomal proteins in response to zinc replete conditions. Sequence alignments and structural studies of related Fur family proteins suggest that BsZur may contain three zinc-binding sites (sites 1-3). Mutational analyses confirm the essential structural role of site 1, while mutants affected in sites 2 and 3 retain partial...
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