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PerR Controls Oxidative Stress Resistance and Iron Storage Proteins and Is Required for Virulence in <i>Staphylococcus aureus</i>

1 Jun 2001

Abstract excerpt

The Staphylococcus aureus genome encodes three ferric uptake regulator (Fur) homologues: Fur, PerR, and Zur. To determine the exact role of PerR, we inactivated the gene by allelic replacement using a kanamycin cassette, creating strain MJH001 (perR). PerR was found to control transcription of the genes encoding the oxidative stress resistance proteins catalase (KatA), alkyl hydroperoxide reductase (AhpCF),...

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PMID: 11349039
DOI: 10.1128/iai.69.6.3744-3754.2001

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PerR Controls Oxidative Stress Resistance and Iron Storage Proteins and Is Required for Virulence in <i>Staphylococcus aureus</i>PMID 11349039Read ↗

In Staphylococcus aureus, fur is an interactive regulator with PerR, contributes to virulence, and Is necessary for oxidative stress resistance through positive regulation of catalase and iron homeostasis.Semantic proximity Read ↗

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