Article
Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2011
Zhang Xing, Brann Terrence W, Zhou Ming, Yang Jun, Oguariri Raphael M, Lidie Kristy B, Imamichi Hiromi, Huang Da-Wei, Lempicki Richard A, Baseler Michael W, Veenstra Timothy D, Young Howard A, Lane H Clifford, Imamichi Tomozumi
Abstract excerpt
Cytosolic foreign DNA is detected by pattern recognition receptors and mainly induces type I IFN production. We found that transfection of different types of DNA into various untreated cells induces type III IFN (IFN-λ1) rather than type I IFN, indicating the presence of uncharacterized DNA sensor(s). A pull-down assay using cytosolic proteins identified that Ku70 and Ku80 are the DNA-binding proteins. The...
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