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Article

A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon.

Journal of virology - 1 Mar 2008

Sanchez David Jesse, Miranda Daniel, Arumugaswami Vaithilingaraja, Hwang Seungmin, Singer Adam E, Senaati Ashkon, Shahangian Arash, Song Moon Jung, Sun Ren, Cheng Genhong

Abstract excerpt

Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18077715
DOI: 10.1128/JVI.01718-07
PMCID: PMC2258961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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