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Cytoplasmic‐translocated Ku70 senses intracellular DNA and mediates interferon‐lambda1 induction

6 Feb 2021

Abstract excerpt

We have previously identified that human Ku70, a nuclear protein, serves as a cytosolic DNA sensor. Upon transfection with DNA or infection with DNA virus, Ku70 translocates from the nucleus into the cytoplasm and then predominately induces interferon lambda1 (IFN-λ1) rather than IFN-alpha or IFN-beta, through a STING-dependent signalling pathway. However, a detailed mechanism for Ku70 cytoplasmic translocation...

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PMID: 33548066
DOI: 10.1111/imm.13318

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