Article
Apoptosis gene polymorphisms and risk of prostate cancer: a hospital-based study of German patients treated with brachytherapy.
Urologic oncology - 1 Jan 2013
Meyer Andreas, Coinac Irina, Bogdanova Natalia, Dubrowinskaja Natalia, Turmanov Nurzhan, Haubold Sabine, Schürmann Peter, Imkamp Florian, von Klot Christoph, Merseburger Axel S, Machtens Stefan, Bremer Michael, Hillemanns Peter, Kuczyk Markus A, Karstens Johann H, Serth Jürgen, Dörk Thilo
Abstract excerpt
BACKGROUND AND OBJECTIVES: Prostate cancer has a genetic component, and single nucleotide polymorphisms (SNPs) can contribute to the risk. We aimed to investigate the role of polymorphisms in 10 candidate genes with a key function in apoptosis. METHODS AND MATERIALS: Eight coding SNPs were chosen in ATM (Ser49Cys), BID (Ser56Cys), CASP8 (Asp302His), CASP10 (Val410Ile), LGALS3 (Pro64His), RASSF1 (Ser133Ala), TP53...
Topics
- Adult
- Aged
- Aged, 80 and over
- Apoptosis
- Apoptosis Regulatory Proteins
- Biomarkers, Tumor
- Brachytherapy
- Case-Control Studies
- Follow-Up Studies