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Article

ATM polymorphisms as risk factors for prostate cancer development.

British journal of cancer - 16 Aug 2004

Angèle S, Falconer A, Edwards S M, Dörk T, Bremer M, Moullan N, Chapot B, Muir K, Houlston R, Norman A R, Bullock S, Hope Q, Meitz J, Dearnaley D, Dowe A, Southgate C, Ardern-Jones A, Easton D F, Eeles R A, Hall J

Abstract excerpt

The risk of prostate cancer is known to be elevated in carriers of germline mutations in BRCA2, and possibly also in carriers of BRCA1 and CHEK2 mutations. These genes are components of the ATM-dependent DNA damage signalling pathways. To evaluate the hypothesis that variants in ATM itself might be associated with prostate cancer risk, we genotyped five ATM variants in DNA from 637 prostate cancer patients and...

Topics

Adult
Aged
Aged, 80 and over
Ataxia Telangiectasia Mutated Proteins
Case-Control Studies
Cell Cycle
Cell Cycle Proteins
DNA-Binding Proteins
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Pedigree

Phenotype

Point Mutation

Polymorphism, Genetic

Prostatic Neoplasms

Protein Serine-Threonine Kinases

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 15280931
DOI: 10.1038/sj.bjc.6602007
PMCID: PMC2364767

Genes

ATM
BRCA1
BRCA2
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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ATM polymorphisms as risk factors for prostate cancer development.PMID 15280931Read ↗

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