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DNA repair gene polymorphisms, tumor control, and treatment toxicity in prostate cancer patients treated with permanent implant prostate brachytherapy.

The Prostate - 1 May 2020

Carignan Damien, Lessard Trystan, Villeneuve Lyne, Desjardins Sylvie, Magnan Sindy, Després Philippe, Martin André-Guy, Foster William, Guillemette Chantal, Lévesque Éric, Vigneault Eric

Abstract excerpt

BACKGROUND: Radiotherapy and brachytherapy are common treatments for localized prostate cancer (PCa). However, very few studies evaluated the association of variations in DNA damage response genes and treatment outcomes and toxicity in brachytherapy-treated patients. PURPOSE: To evaluate the association of inherited germline variations in DNA repair-associated genes with tumor control and treatment toxicity in...

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PMID: 32201973
DOI: 10.1002/pros.23975

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