A minor arginine tRNA mutant limits translation preferentially of a protein dependent on the cognate codon.

doi:10.1128/jb.172.5.2504-2510.1990

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Article

A minor arginine tRNA mutant limits translation preferentially of a protein dependent on the cognate codon.

Journal of bacteriology - 1 May 1990

Chen K S, Peters T C, Walker J R

Abstract excerpt

The Escherichia coli argU gene encodes a rare arginine tRNA (anticodon UCU) that translates the similarly rare AGA codon. The argU10(Ts) mutation is a transition that changes the first nucleotide of the mature tRNA from G to A, presumably destabilizing the acceptor stem. This mutation, when present in haploid condition in the chromosome, reduces the growth rate at 30 degrees C and results in cessation of growth...

Topics

Alleles
Anticodon
Bacteriophage lambda
Base Sequence
Chromosome Mapping
Chromosomes, Bacterial
Cloning, Molecular
Codon
DNA, Bacterial
DNA, Recombinant
Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Bacterial

Molecular Sequence Data

Mutation

Nucleic Acid Conformation

Protein Biosynthesis

RNA, Transfer, Amino Acid-Specific

RNA, Transfer, Arg

Source

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Identifiers

PMID: 2139647
DOI: 10.1128/jb.172.5.2504-2510.1990
PMCID: PMC208890

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2139647-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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