Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a commonly used mouse model of SMA reveals increased seizure susceptibility and heightened fear response in FVB/N mice.

Neurobiology of disease - 1 Jul 2011

Gogliotti Rocky G, Lutz Cathleen, Jorgensen Michael, Huebsch Kimberly, Koh Sookyong, Didonato Christine J

Abstract excerpt

The SMN2 transgenic mouse, Tg(SMN2)89Ahmb, has emerged as the most widely used in spinal muscular atrophy (SMA) research. Here we clone the genomic integration site of the transgene and demonstrate it to be in intron 4 of the metabotropic glutamate receptor 7 (mGluR7) gene. We found that the integration of this transgene significantly reduced both mGluR7 mRNA and protein levels (24% and 9%, respectively). To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epilepsy
Share to Fear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integration Host Factors

Share to Introns

Share to Muscular Atrophy, Spinal

Share to Receptors, Metabotropic Glutamate

Share to Survival Analysis

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 21396450
DOI: 10.1016/j.nbd.2011.03.002
PMCID: PMC3679180

Genes

SMN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a commonly used mouse model of SMA reveals increased seizure susceptibility and heightened fear response in FVB/N mice.PMID 21396450Read ↗

Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy.Semantic proximity Read ↗

Molecular and phenotypic reassessment of an infrequently used mouse model for spinal muscular atrophy.Semantic proximity Read ↗

Conditional Single Vector CRISPR/SaCas9 Viruses for Efficient Mutagenesis in the Adult Mouse Nervous System.Semantic proximity Read ↗

Genetic mouse models of migraineSemantic proximity Read ↗

A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment.Semantic proximity Read ↗

Transient neuromotor phenotype in transgenic spastic mice expressing low levels of glycine receptor beta-subunit: an animal model of startle disease.Semantic proximity Read ↗

Intracerebroventricular SPAST-AAV9 gene therapy prevents manifestation of symptoms in a mouse model of SPG4 hereditary spastic paraplegia.Semantic proximity Read ↗

Identification of a battery of tests for drug candidate evaluation in the SMNDelta7 neonate model of spinal muscular atrophy.Semantic proximity Read ↗

Characterization of behavioral and neuromuscular junction phenotypes in a novel allelic series of SMA mouse models.Semantic proximity Read ↗

Behavioural phenotyping reveals anxiety-like features of SV2A deficient mice.Semantic proximity Read ↗

Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors.Semantic proximity Read ↗

Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.