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Article

Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy.

Neurobiology of disease - 1 Aug 2007

Butchbach Matthew E R, Edwards Jonathan D, Burghes Arthur H M

Abstract excerpt

Spinal muscular atrophy (SMA) is a recessive motor neuron disease that affects motor neurons in the anterior horn of the spinal cord. SMA results from the reduction of SMN (survival motor neuron) protein. Even though SMN is ubiquitously expressed, motor neurons are more sensitive to the reduction in SMN than other cell types. We have previously generated mouse models of SMA with varying degrees of clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17561409
DOI: 10.1016/j.nbd.2007.04.009
PMCID: PMC2700002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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