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Article

Molecular and phenotypic reassessment of an infrequently used mouse model for spinal muscular atrophy.

Biochemical and biophysical research communications - 1 Jan 2010

Gogliotti Rocky G, Hammond Suzan M, Lutz Cathleen, Didonato Christine J

Abstract excerpt

Proximal spinal muscular atrophy (SMA) results from loss of the survival motor neuron 1 (SMN1) gene, with retention of its nearly identical homolog, SMN2. There is a direct correlation between disease severity and SMN2 copy number. Mice do not have a Smn2 gene, and thus cannot naturally replicate the disorder. However, two murine models of SMA have been generated using SMN2-BAC transgenic mice bred onto a mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19961830
DOI: 10.1016/j.bbrc.2009.11.090
PMCID: PMC2814331

Genes

SMN2
SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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