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Article

Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms.

PloS one - 24 Feb 2011

Lagging Martin, Askarieh Galia, Negro Francesco, Bibert Stephanie, Söderholm Jonas, Westin Johan, Lindh Magnus, Romero Ana, Missale Gabriele, Ferrari Carlo, Neumann Avidan U, Pawlotsky Jean-Michel, Haagmans Bart L, Zeuzem Stefan, Bochud Pierre-Yves, Hellstrand Kristoffer

Abstract excerpt

BACKGROUND: High baseline levels of IP-10 predict a slower first phase decline in HCV RNA and a poor outcome following interferon/ribavirin therapy in patients with chronic hepatitis C. Several recent studies report that single nucleotide polymorphisms (SNPs) adjacent to IL28B predict spontaneous resolution of HCV infection and outcome of treatment among HCV genotype 1 infected patients. METHODS AND FINDINGS: In...

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PMID: 21390311
DOI: 10.1371/journal.pone.0017232
PMCID: PMC3044738

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